Fig. 6: Genetic alterations (amplification, gain, shallow deletion, deep deletion, and point mutations) in DNA repair genes in PCa patients with YWHAZ amplifications and high YWHAZ mRNA and protein levels (TCGA-PRAD data set, n = 499).

a Mutational landscape analysis (amplification, gain, shallow deletion, deep deletion, and point mutations) of DNA repair genes in patients with no alterations in YWHAZ (n = 331) and with amplifications in YWHAZ (n = 35). Each vertical line is a patient and the different colors represent alterations in a different gene, as specified in the references. The graph includes box plots showing the median number of altered DNA repair genes. The top and bottom of each rectangular box represent the 75th and 25th percentiles respectively, with the median indicated with a solid line inside the box. Horizontal bars extending from each box represent more extreme values defined as 1.5-times the interquartile range (25th percentile subtracted from the 75th percentile) above the 75th percentile or below 25th percentile. Student’s t-test was used to ascertain statistical significance. b Bar plots representing the percentage of PCa patients that present genetic alterations in each DNA repair gene based on whether they have amplifications in YWHAZ (red bars), high or low YWHAZ mRNA levels (blue bars), and high or low 14-3-3ζ/δ protein levels (green bars). c Comparative table of the percentage of patients that present genetic alterations in each DNA repair gene based on whether they have amplifications in YWHAZ, high or low YWHAZ mRNA levels, and high or low 14-3-3ζ/δ protein levels. Fisher’s exact test was used to test the statistical significance of contingency tables of genetic alterations. Statistical significance was set at P ≤ 0.05. *P ≤ 0.05, **P ≤ 0.01, ***P < 0.001.