Fig. 2: Time-killing curves, stability, and resistance of SCPs-A6 and G6 against MDR E. coli CVCC195 and their toxicity toward eukaryotic cells. | Communications Biology

Fig. 2: Time-killing curves, stability, and resistance of SCPs-A6 and G6 against MDR E. coli CVCC195 and their toxicity toward eukaryotic cells.

From: Development of chimeric peptides to facilitate the neutralisation of lipopolysaccharides during bactericidal targeting of multidrug-resistant Escherichia coli

Fig. 2

a The time-killing curves of A6, G6 and N6 against E. coli CVCC195 in vitro. Control: PBS. PMB: polymyxin B. b–e Effects of temperature (b), pH (c), enzyme (d), serum (e) on the antibacterial activity of A6, G6, and N6 against E. coli CVCC195. f The peptide remaining in serum. g Resistance of A6 and G6. h The hemolysis of A6 and G6 against fresh mouse red blood cells. 0.1% Triton X-100 served as the positive control (100% hemolysis). i The cytotoxicity of A6 and G6 against RAW 264.7 monocytes. Results indicate means with SD (n = 3 independent experiments). Different lower case letters indicate a difference between two groups (p < 0.05). Source data for a–d can be found in Supplementary Data.

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