Table 2 MIC values of the SCPs, PMB, and control peptides.

From: Development of chimeric peptides to facilitate the neutralisation of lipopolysaccharides during bactericidal targeting of multidrug-resistant Escherichia coli

Strains

MIC

A6

G6

N6

PMB

LBP14

LBPN6

N6CK

A6CK

G6CK

μg per ml

μM

μg per ml

μM

μg per ml

μM

μg per ml

μM

μg per ml

μM

μg per ml

μM

μg per ml

μM

μg per ml

μM

μg per ml

μM

Gram-negative bacteria

 Escherichia coli CVCC195a

8

1.5

4

0.88

1

0.4

1

0.84

8

4.53

64

15.2

>64

>25.8

64

12.4

32

7.1

 E. coli CVCC1515a

16

3

16

3.52

1

0.4

1

0.84

8

4.53

32

7.6

>64

>25.8

>64

>12.4

16

3.5

 Salmonella typhimurium ATCC14028c

8

1.5

4

0.88

4

1.6

2

1.68

16

9.06

32

7.6

>64

>25.8

>64

>12.4

32

7.1

 S. pullorum CVCC533a

16

3

16

3.52

2

0.8

1

0.84

32

18.1

32

7.6

>64

>25.8

>64

>12.4

>64

>14.2

 S. pullorum CVCC1809a

8

1.5

8

1.76

2

0.8

1

0.84

16

9.06

32

7.6

>64

>25.8

>64

>12.4

32

7.1

 Pseudomonas aeruginosa CICC10419b

>64

>12

16

3.52

16

6.4

>64

>53.76

64

36.2

64

15.2

>64

>25.8

>64

>12.4

>64

>14.2

Gram-positive bacteria

 Staphylococcus aureus ATCC43300c

>64

>12

16

3.52

16

6.4

>64

>53.76

64

36.2

64

15.2

>64

>25.8

>64

>12.4

>64

>14.2

 Enterococcus faecalis CVCC3936a

32

6

16

3.52

32

12.8

>64

>53.76

32

18.1

8

1.9

>64

>25.8

>64

>12.4

16

3.5

 Streptococcus suis CVCC606a

32

6

16

3.52

64

25.6

>64

>53.76

>64

>36.2

32

7.6

>64

>25.8

>64

>12.4

>64

>14.2

 Bacillus subtilis ATCC6633c

8

1.5

8

1.76

1

0.4

0.5

0.42

32

18.1

16

3.8

>64

>25.8

16

3.1

4

0.9

 Listeria ivanovii ATCC19119c

>64

>12

>64

>14.08

>64

>25.6

>64

>53.76

8

4.53

8

1.9

>64

>25.8

>64

>12.4

8

1.8

Fungi

 Candida albicans CGMCC2.2411d

>64

>12

>64

>14.08

>64

>25.6

>64

>53.76

>64

>36.2

>64

>15.2

>64

>25.8

>64

>12.4

>64

>14.2

  1. Data are representative of three independent experiments. The MDR E. coli CVCC195 strain is resistant to tetracyclines (doxycycline), penicillins (benzocillin and penicillin), lincosamides (lincomycin and clindamycin), glycopeptides (vancomycin), amphenicols (chloramphenicol), macrolipids (erythromycin), aminoglycosides (amikacin, streptomycin and gentamicin) and sulfonamides (sulfamethoxazole), respectively.
  2. PMB: polymyxin B; NN: no detection, N6CK: N6 scramble control, A6CK: A6 scramble control, G6CK: G6 scramble control.
  3. aChina Veterinary Culture Collection Center (CVCC).
  4. bChina Center of Industrial Culture Collection (CICC).
  5. cAmerican Type Culture Collection (ATCC).
  6. dChina General Microbiological Culture Collection Center (CGMCC).
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