Table 1 ΔTm of the proteins conjugated with ebselen-based and ebsulphur-based derivatives.
From: Ebselen as template for stabilization of A4V mutant dimer for motor neuron disease therapy
Compounds | ΔTm (°C) | |||
|---|---|---|---|---|
WT | A4V | WTC6S | A4VC6S | |
Ebselen | −10.5* | −3.1 | 5.6 | 8.8 |
Cpd 1 | 1.0 | −1.7 | 3.3 | 4.5 |
Cpd 2 | −0.1 | −0.4 | 3.1 | 4.0 |
Cpd 3 | – | – | 5.4 | 8.8 |
Cpd 4 | – | – | 3.7 | 6.7 |
Cpd 5 | – | – | 4.8 | 8.7 |
Cpd 6 | −9.9* | −4.7 | −6.6* | −2.6 |
Cpd 7 | – | – | −0.6 | −3.4 |
Cpd 8 | – | – | 3.0 | 3.9 |
Cpd 9 | – | – | 1.7 | 1.3 |
Cpd 10 | – | – | 3.4 | 3.9 |
Ebsulphur | −0.3 | −0.1 | 0.6 | 2.4 |
Cpd 12 | – | – | 2.8 | 3.8 |
Cpd 13 | – | – | 1.4 | 0.5 |
Cpd 14 | – | – | 0.2 | −1.5 |
Cpd 15 | – | – | 0.5 | −1.5 |
Cpd 16 | – | – | 0.8 | 1.5 |
Cpd 17 | – | – | 0.5 | 1.2 |
Cpd 18 | – | – | 0.6 | 2.0 |
Cpd 19 | – | – | 3.1 | 3.3 |
Cpd 20 | – | – | 2.7 | 4.9 |
