Fig. 1: Schematic representation of the general domain organization of SSSCA1.
From: Sjögren syndrome/scleroderma autoantigen 1 is a direct Tankyrase binding partner in cancer cells
a Domain organization of human SSSCA1, aligned with a disorder probability plot and localization of the three domains. Numbers denote amino acid positions. Zn, N-terminal zinc-binding domain (residues 20–86). Pro, proline-rich region (residues 86–148). The C-terminal helical domain can be subdivided into two predicted α-helices H1 (150–167) and H2 (173–195). b Schematic domain organization of representative SSSCA1 orthologs. Zn, N-terminal zinc-binding domain. Pro, proline-rich region. H, C-terminal helical domain. Percentage of positive identities to human SSSCA1 is indicated. c Phylogenetic tree of SSSCA1. Orthologs’ sequences retrieved from Ensembl, Genbank, or UniProt were aligned and a phylogenetic tree was constructed using the neighbor-joining tree method. Kingdoms, major phyla, and taxonomical groups are indicated. For clarity, vertebrate and invertebrate species are shown in red and blue nuances, respectively.
