Fig. 1: Outline of the CARMA algorithm.
From: DNA copy number motifs are strong and independent predictors of survival in breast cancer
a Complete analysis pipeline. b Steps included in the CARMA analysis. The input is one or more allele-specific copy number profiles. The algorithm extracts local features and accumulates these across genomic regions to form six regional scores. c Calculation of CARMA scores within a specified region. d Prototype patterns captured by each of the six CARMA scores. e An application of the algorithm to three breast tumor samples in the Oslo2 cohort. Lower panel: total copy number and allele fraction as a function of genomic locus. Upper panel: circos plots of regional (arm-wise) CARMA scores.
