Fig. 4: BMPR2-deficiency impairs fatty acid metabolism and oxidative phosphorylation.
From: BMPR2 promotes fatty acid oxidation and protects white adipocytes from cell death in mice
a Gene ontology analysis for downregulated genes in KEGG pathways, pathways with FDR < 0.1 and p value < 0.00015 were listed and grouped designated with different color. b Pathways with FDR < 0.1 and p value < 0.00015 were visualized in Cytoscape v.3.4.0, the node sizes and color presented p value and FDR, respectively. c Downregulated genes identified by sequencing involved fatty acid metabolism and oxidative phosphorylation. d Real-time PCR validation of genes selected from pathways in c. Total RNA were isolated from mature adipocyte isolated from inguinal fat (n = 6). Data are expressed as means ± SD. *p < 0.05, **p < 0.01. e−g Correlation between mRNA level of BMPR2 and indicated genes of human adipose tissue samples determined by quantitative PCR.
