Fig. 5: Super-resolution (dSTORM) microscopy reveals that aCMs are sensitive to chemical perturbations in vitro. | Communications Biology

Fig. 5: Super-resolution (dSTORM) microscopy reveals that aCMs are sensitive to chemical perturbations in vitro.

From: Functional culture and in vitro genetic and small-molecule manipulation of adult mouse cardiomyocytes

Fig. 5

a dSTORM imaging of aCM to visualize α-actinin, RyR2, DHPR, SERCA2a, and PLN in the absence or presence of tunicamycin-induced protein folding stress (5 µmol L−1 for 24 h vs. a DMSO sham). Scale bars represent 10 µm, magnified inset images are 4 × 4 µm. b Voronoi tessellation cluster area and density analysis of dSTORM-imaged aCMs (N = 3) for α-actinin (b), RyR2 (c), DHPR (d), SERCA2A (e), and PLN (f).

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