Fig. 2: Mapping of mutations found in viruses isolated from mAb-treated mice. | Communications Biology

Fig. 2: Mapping of mutations found in viruses isolated from mAb-treated mice.

From: Triple combination therapy of favipiravir plus two monoclonal antibodies eradicates influenza virus from nude mice

Fig. 2

Amino acid substitutions found in the HA of viruses isolated from the lungs of mice treated with anti-Stem and anti-RBS mAbs were mapped onto the 3D structure of the H1–HA trimer (PDB; 3LZG) by using the molecular graphics system PyMOL. The amino acid at position 200 is not exposed on the molecular surface of this model and the amino acids at positions 327, 509, and 516 are not included in this model. Cyan indicates amino acids involved in receptor binding and orange indicates alpha helix A in the HA stem, which is the major epitope in the HA stem. Mutations shown in red are shown with H1 numbering.

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