Table 3 Susceptibility of isolated viruses to FAV.

From: Triple combination therapy of favipiravir plus two monoclonal antibodies eradicates influenza virus from nude mice

Group number

Treatment with

Days post infection

IC50 valuea (μg/ml)

3

FAV

28b

2.3

  

28

2.1

  

28

1.6

  

38

2.0

  

38

1.7

  

42

1.7

  

43

2.3

6

FAV + Anti-Stem mAb

28

1.8

  

28

1.7

  

28

2.0

  

51

1.9

  

117

1.8

  

122

2.3

  

138

2.3

7

FAV + Anti-RBS mAb

28

NAc

  

28

NA

  

28

NA

  

51

1.1

  

58

4.7

  

85

1.1

  

100

2.3

  1. aIC50 value of wild-type virus to FAV was 1.3 μg/ml.
  2. bBolded numbers indicated that three out of three plaque-purified viruses were susceptible to FAV.
  3. cVirus was not isolated.
Back to article page