Table 4 Amino acid substitutions in HA of viruses isolated from lungs of treated mice.

From: Triple combination therapy of favipiravir plus two monoclonal antibodies eradicates influenza virus from nude mice

Group number

Treatment with

Days post infection

Amino acid mutation(s) in HAa

4

Anti-Stem mAb

14

None

  

14

None

  

14

None

  

51

None

  

51

L192I

5

Anti-RBS mAb

14

D188N

  

14

None

  

14

None

  

37

None

6

FAV + Anti-Stem mAb

14

None

  

14

V200I and S327Y

  

14

None

  

51

D128E

  

117

A49T, P125S, T198A, Q390H, and T392I

  

122

L192I

  

138

L192I, T509A, and R516W

7

FAV + Anti-RBS mAb

14

NAb

  

14

NA

  

14

None

  

51

None

  

58

None

  

85

None

  

100

L192I

8

Anti-Stem mAb + Anti-RBS mAb

14

None

  

14

None

  

14

None

  

39

None

  

39

None

  

51

None

  

155

S186N, L192I, Y362H, and R516G

  1. aH1 numbering.
  2. bVirus was not isolated.