Fig. 9: Scheme summarizing the different profiles of interaction between Tupanvirus and virophages described in our study. | Communications Biology

Fig. 9: Scheme summarizing the different profiles of interaction between Tupanvirus and virophages described in our study.

From: A virophage cross-species infection through mutant selection represses giant virus propagation, promoting host cell survival

Fig. 9

a Coinfection of A. castellanii with Zamilon and Tupanvirus at low to moderate MOI (MOI ≤ 10) leads to replication of both Tupanvirus and virophage. b Guarani wild-type (WT) is not able to replicate with Tupanvirus in primo coinfection, but this first passage allows the selection of a mutant genotype adapted to the virus. c The mixture containing mutant Guarani is able to propagate with Tupanvirus and seems to be highly virulent, leading to the abolition of Tupanvirus morphogenesis. d Tupanvirus at high MOI (MOI ≥ 100) triggers its cytotoxic profile in host cells. Although the virus cannot replicate at this MOI, this feature allows it to prevent virophage parasitism. N.D.: Not detected.

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