Fig. 2: TA and DOP accelerate wound healing in vitro in a wound-mimicking assay.
From: Trace amines produced by skin bacteria accelerate wound healing in mice
a TA and DOP (each at 25 μg/ml) were added into the HaCaT cell culture seeded with a gap in the presence of EPI (25 μg/ml). ICI 118551 was used as positive control. Microscopic images of the gaps were taken at time 0 h and 24 h. b The gap closing, which was calculated using ImageJ67, revealed that TA and DOP abrogated the migration-inhibiting effect of EPI. c In the absence of EPI, the TA, DOP and ICI showed similar gap closing as control. Each data point is the mean value ± SEM from 4 independent replicates for (b) and 3 independent replicates for (c), *p < 0.05; **p < 0.01; and ***p < 0.001, data were analyzed using Student's t test. Source data are provided as a Supplementary Data 1 file.
