Fig. 1: Schematic representation of liposomal nanotheranostics for multimode-targeted bioimaging and phototriggered cancer therapy. | Communications Biology

Fig. 1: Schematic representation of liposomal nanotheranostics for multimode-targeted bioimaging and phototriggered cancer therapy.

From: Liposomal nanotheranostics for multimode targeted in vivo bioimaging and near‐infrared light mediated cancer therapy

Fig. 1

a Folic acid targeting ligand decorated self-assembled liposomal nanohybrid loaded multimode imaging probes, viz., gold nanoparticles (AuNPs as radiocontrast for X-ray computed tomography and reactive oxygen species scavenger) and graphene quantum dots (GQDs as fluorescent contrast for near-infrared fluorescence imaging and photothermal agent). Designed functional liposomal nanohybrids demonstrating photothermal response/heat and the generation of reactive oxygen species (ROS, considered as the side product of photothermal therapy) under near-infrared (NIR) light exposure. b NIR light mediated cancer therapeutic representation with tumor-bearing mice model using engineered liposomal nanotheranostic agents and targeted imaging bimodality of breast cancer through X-ray computed tomography (X-ray CT) and in vivo imaging system (IVIS). Liposomal nanotheranostics treated cancer cells displaying the production of ROS (green emission represents the presence of ROS captured by DCFDA (2′,7′-dichlorofluorescin diacetate) dye staining) during NIR light exposure, scale bar = 20 µm.

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