Fig. 7: Site-selective multimode tumor imaging.
a Planned NIR light mediated phototriggered strategy for post-injected 4T1 tumor bearing mice showing enhanced tumor uptake of injected gold nanoparticles (AuNPs) and graphene quantum dots (GQDs) loaded liposomal nanotheranostics with folic acid functionalization (NFGL–FA). b Experimental flowchart from day 0 (cell culture) to tissue collection (36 days) followed by multimodal tumor diagnosis and biodistribution experiment setup. c Localized tumor diagnosis and specific biodistribution measurements after 48 h of time before and after NIR light exposure (750 nm, 1 W/cm2 for 10 min) followed by whole body X-ray computed tomography scans with coronal and axial CT slices of mice body using TOSHIBA 64 CT scanner at 120 kVp tube voltage and 250 mA tube current with 5 mm slice thickness and 1 s rotation time. d Targeted deep tumor localization in mice body before and after NIR light exposure (750 nm, 1 W/cm2 for 10 min) using the in vivo imaging system (IVIS). In both imaging modalities, pre-injected mice were considered as control groups.
