Fig. 6: Glucose-level-dependent insulin release from the device in vivo. | Communications Biology

Fig. 6: Glucose-level-dependent insulin release from the device in vivo.

From: Hollow fiber-combined glucose-responsive gel technology as an in vivo electronics-free insulin delivery system

Fig. 6: Glucose-level-dependent insulin release from the device in vivo.

a Schematic illustration of the experimental design. The device containing human insulin was subcutaneously implanted along with a continuous glucose monitoring system in the back skin of healthy normoglycemic rats. The rats received continuous glucose injection through the right internal jugular vein for the indicated period. b Time course of blood and subcutaneous glucose levels. Glucose solution was continuously injected from 60 to 180 min. c Time course of blood glucose levels and serum human insulin concentrations. Glucose solution was continuously injected from 60 to 180 min.

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