Fig. 7: Therapeutic efficacy for type 1 diabetes in rats. | Communications Biology

Fig. 7: Therapeutic efficacy for type 1 diabetes in rats.

From: Hollow fiber-combined glucose-responsive gel technology as an in vivo electronics-free insulin delivery system

Fig. 7: Therapeutic efficacy for type 1 diabetes in rats.

a Protocol of the experimental design. Type 1 diabetes was induced by the intraperitoneal injection of streptozotocin (STZ, 40 mg/kg body weight) on day −7, and then received subcutaneous implantation of the device containing PBS or human insulin on day 0. b Time course of blood glucose levels and serum human insulin concentrations under ad lib fed conditions. c HbA1c levels before and 7 days after implantation of the device. d Time course of the amount of daily water intake. *P < 0.05 and **P < 0.01 vs. the PBS group. n = 6–8.

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