Fig. 2: LRP1 expression in different cell linages that are important for cardiac development in the developing heart. | Communications Biology

Fig. 2: LRP1 expression in different cell linages that are important for cardiac development in the developing heart.

From: Mutation of LRP1 in cardiac neural crest cells causes congenital heart defects by perturbing outflow lengthening

Fig. 2

Panel a is schematic representation of embryonic heart showing AVC and OFT (conal part and truncal part). Immunostaining in E9.5 and E10.5 embryos demonstrated LRP1 is expressed in mesenchymal cells in the endocardial cushion, with no expression seen in the CD31 positive endocardium (b–d) at E10.5; epicardium (e white arrow) at E10.5 pharyngeal endoderm and pharyngeal arch (b, f) at E10.5, neural crest/mesenchymal cells (g–i) at E9.5; outflow tract (i) at E9.5, outflow tract (j) at E10.5 and truncal artery (k) at E10.5. LRP1 and Islet-1 (ISL1) are expressed in (f) pharyngeal endoderm and pharyngeal mesoderm. LRP1 and AP2α both expressed in the neural crest/mesenchymal cells (g–i) and outflow tract (j–l). i The magnified view from the white box of figure (h). Scale bars: 50 µm.

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