Table 2 Area under the curve (AUC) values with 95% confidence intervals for baseline and 2-month signatures for prediction of treatment outcome at 2 months (Early Responders) and at 6 months (TB Cures).
Validation | Outcome | Time of prediction | N | Patient characteristics | Transcriptional biomarkers | Patient + transcriptional biomarkers | N | Patient characteristics | Protein biomarkers | Patient + protein biomarkers |
|---|---|---|---|---|---|---|---|---|---|---|
Internal | TB Cures (6 months) | Baseline | 90 | 0.78 (0.68–0.88) | 0.78 (0.69–0.88) | 0.89 (0.83–0.95) | 83 | 0.78 (0.68–0.88) | 0.69 (0.57–0.81) | 0.83 (0.74–0.92) |
TB Cures (6 months) | 2 months | 67 | 0.83 (0.71–0.94) | 0.84 (0.73–0.95) | 0.97 (0.91–1.00) | 59 | 0.74 (0.59–0.89) | 0.68 (0.51–0.85) | 0.68 (0.51–0.84) | |
Early responders (2 months) | Baseline | 90 | 0.77 (0.66–0.87) | 0.67 (0.55–0.79) | 0.97 (0.94–1.00) | 83 | 0.74 (0.63–0.85) | 0.78 (0.68–0.88) | 0.88 (0.80–0.95) | |
External | TB Cure (6 months) | Baseline | 84 | 0.71 (0.58–0.85) | 0.74 (0.54–0.94) | 0.92 (0.84–1.00) | – | – | – | – |
