Table 1 Shortlisted putative predictive biomarkers for rehabilitation outcome, as detected by RNA-seq of tumor tissue.

From: Molecular characterization of a marine turtle tumor epizootic, profiling external, internal and postsurgical regrowth tumors

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GFF symbol

GFF description

Florida cohort

Texas cohort

   

Log2 fold change

padj

Log2 fold change

padj

Gene18158

Pycard

Apoptosis-associated speck protein containing a CARD

3.03

1.34E−46

2.00

3.47E−06

Gene17537

LOC102936464

Cyclic GMP-AMP synthase

5.15

2.47E−35

3.73

7.68E−09

Gene15121

LOC102947706

Proteasome subunit alpha type-6

2.97

2.93E−25

2.86

1.85E−14

Gene11831

Ifi6

Interferon alpha-inducible protein 6

4.92

1.23E−22

5.68

1.08E−43

Gene3090

LOC102943254

Uncharacterized protein LOC102943254

3.051

8.86E−21

5.53

1.65E−26

Gene17471

LOC102940704

Interferon alpha-inducible protein 27 protein 2B

4.65

1.21E−20

5.22

1.01E−20

Gene2107

LOC102940281

Uncharacterized protein LOC102940281, partial

3.86

1.00E−19

5.59

5.25E−31

Gene17278

Batf2

Basic leucine zipper transcriptional factor ATF 2

2.94

4.81E−19

3.75

2.11E−21

Gene7946

LOC102934626

Interferon alpha-inducible protein 27 protein 2

3.08

1.07E−18

5.00

7.84E−23

Gene12380

Myh6

Myosin-6

3.75

1.74E−18

3.86

7.28E−07

Gene11311

LOC102934712

GTPase IMAP family member 3, partial

6.33

4.81E−18

5.82

2.16E−12

  1. Florida cohort: good outcome is release, whereas poor outcome is died/euthanized in care. Texas cohort (all turtles released): good outcome is two rounds of surgery or less, along with 200 days in rehabilitation.
  2. GFF general feature format, padj-adjusted P value, CARD C-terminal caspase-recruitment domain, ATF activating transcription factor family, IMAP immunity-associated proteins.