Fig. 2: Amylin deposition in the heart sections of NHPs with HF. | Communications Biology

Fig. 2: Amylin deposition in the heart sections of NHPs with HF.

From: Amylin deposition activates HIF1α and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primates

Fig. 2

a–f Amylin staining visualized with DAB chromogen. a Positive staining for amylin in pancreas from CTL NHPs. b No amylin deposits were observed in the CTL heart (n = 7). c–f Amylin deposition in the nucleus (c), hypertrophic cardiomyocyte sarcolemma (c and d), inflammatory cells (e), and blood cells (f) of the HF group (n = 6). g Bar graph presented the relative positive signal intensity for amylin in a 284 × 214 μm field of view of heart sections from NHPs with CTL (n = 7) and HF (n = 6). Scale bar, 100 µm. Data represent mean ± SEM, *P < 0.05 by student’s t test.

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