Fig. 3: Circulating amylin and HF markers levels in NHPs. | Communications Biology

Fig. 3: Circulating amylin and HF markers levels in NHPs.

From: Amylin deposition activates HIF1α and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primates

Fig. 3

a Amylin concentration in serum from a parallel set of NHPs (CTL, n = 10; HF, n = 7). b Protein levels of ST2, GDF-15, and cTnI in serum as in panel (a). c–e The correlations between serum amylin level and ST2 (c), cTnI (d), and GDF-15 (e), respectively, in serum as in panel (a) and (b). Amylin levels in matched plasma (f) and RBC lysates (g) from the same animals whose hearts were used for histopathological evaluation in Fig. 1 and amylin assessment in Fig. 2 (CTL, n = 7; HF, n = 6). Data represent mean ± SEM. *P < 0.05; **P < 0.01 by Student’s t test. The correlations between serum amylin level and ST2 (c), cTnI (d), and GDF-15 (e), respectively, were analyzed by Spearman nonparametric correlation analysis in GraphPad 7.04 (GraphPad Inc., San Diego, CA), and the values for the Spearman r were indicated on the plots.

Back to article page