Table 1 Comparison of cardiac functions parameters of NHPs.

From: Amylin deposition activates HIF1α and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primates

Groups

CTL

HF

Systolic BP (mmHg)

119.79 ± 8.89

117.48 ± 7.04

Diastolic BP (mmHg)

75.15 ± 6.32

73.93 ± 2.69

Heart beat (bpm)

181.33 ± 4.42

168.38 ± 12.61

PR interval (ms)

63.09 ± 6.53

63.34 ± 16.89

RR interval (ms)

339.00 ± 8.75

335.17 ± 33.11

QRS complex (ms)

51.53 ± 1.85

84.94 ± 6.11***

QT interval (ms)

287.70 ± 22.24

187.60 ± 24.39*

QTc interval (ms)

345.81 ± 21.99

242.63 ± 37.79*

LVSP (mmHg)

94.79 ± 1.59

110.63 ± 9.44*

LVDP (mmHg)

0.79 ± 0.62

11.98 ± 7.17*

+dp/dt max (mmHg/s)

4141.67 ± 204.27

3173.71 ± 311.99*

–dp/dt max (mmHg/s)

3273.58 ± 94.45

2357.84 ± 299.59**

EF (%)

68.06 ± 0.63

29.05 ± 5.58***

FS (%)

31.66 ± 0.45

16.42 ± 4.96**

EDV (mL)

3.70 ± 0.52

13.53 ± 2.12***

ESV (mL)

1.18 ± 0.16

9.87 ± 1.98***

SV (mL)

2.52 ± 0.36

3.66 ± 0.82

LVIDd

1.52 ± 0.08

2.31 ± 0.23**

LVIDs

1.04 ± 0.05

1.87 ± 0.19***

MV E/A ratio

1.56 ± 0.05

1.35 ± 0.06*

LV mass (g)

5.14 ± 1.01

20.92 ± 5.09**

  1. Data represent mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 by Student’s t test. Control (CTL) group, n = 7; heart failure (HF) group, n = 6. QTc corrected QT, LVSP left ventricular systolic pressure, LVDP left ventricular diastolic pressure, +dp/dt max maximum rate of rise of left ventricular pressure, –dp/dt max maximum rate of fall of left ventricular pressure, EF ejection fraction, FS fraction shortening, EDV end-diastolic volume, ESV end-systolic volume, LVIDd left ventricular end-diastolic internal diameter, LVIDs left ventricular end-systolic internal diameter, MV E/A ratio the ratio of mitral peak E-wave velocity and mitral peak A-wave velocity, LV mass left ventricular mass.
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