Fig. 3: CLEC18A and CLEC18A(S339R) modulate type I/III IFN expression and virus replication in lung alveolar epithelial cells.
From: Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection
Pulmonary alveolar epithelial cells (2 × 105/well) from WT, ROSA-CLEC18A, and ROSA-CLEC18A(S339R) mice were incubated with H5N1 virus (MOI = 2) for 12 h, followed by harvesting cells to determine cytokine expression (a) and virus replication (b) by quantitative RT-PCR (n = 7–12). One-way ANOVA was performed. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001, for WT group versus group of CLEC18A or CLEC18A(S339R).
