Fig. 7: CLEC18 enhances poly (I:C)-induced inflammatory reaction in vivo.
From: Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection
WT, ROSA-CLEC18A, and ROSA-CLEC18A(S339R) mice were inoculated with HMW poly (I:C) (30 μg per mouse) via intranasal route, and then were sacrificed at day 1 (D1) and 4 (D4) post treatment. Lung sections were subjected to hematoxylin and eosin (H&E) staining (n = 3–6) (a), and cytokine in bronchoalveolar lavage was determined by ELISA (n = 3–8) (b). pIC: poly (I:C). One-way ANOVA was performed. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001 for WT group versus groups of CLEC18A or CLEC18A(S339R). Scale bar: 200 μM.
