Fig. 2: The evolution and the gender distribution of the top 11 missense mutation ratios.

The blue lines illustrate the evolution of the top 11 missense mutation ratios (the y-axis on the left) computed as the number of genome sequences having a given mutation over the total number of genome sequences. The red lines represent the evolution of the total number of genome sequences (the y-axis on the right). The bar plot is the gender distribution of the ratio of the number of samples having top 11 missense mutations over the total number of samples having age and/or gender labels. Red bars represent the female ratios and the blue bars represent the male ratios in the United States.