Fig. 4: The 3D structure and network analysis plot of SARS-CoV-2 S protein.

a Illustration of S-protein and ACE2 interaction. The RBD is displayed in green, the ACE2 is given in red, and mutation D614G is highlighted in red. b The difference of FRI rigidity index between the network with wild type and the network with mutant type. c The difference of the subgraph centrality between the network with wild type and the network with mutant type.