Fig. 5: The 3D structure and network analysis plot of SARS-CoV-2 ORF3a protein. | Communications Biology

Fig. 5: The 3D structure and network analysis plot of SARS-CoV-2 ORF3a protein.

From: Analysis of SARS-CoV-2 mutations in the United States suggests presence of four substrains and novel variants

Fig. 5

a The 3D structure of SARS-CoV-2 ORF3a protein. b The visualization of SARS-CoV-2 ORF3a proteoform. The high-frequency mutation 25563G>T-(Q57H) on ORF3a is marked in color. The red color represents the wild type and the yellow represents the wild type. c The difference of FRI rigidity index between the network with wild type and the network with mutant type. d The difference of the subgraph centrality between the network with wild type and the network with mutant type. e Sequence alignments for the ORF3a protein of SARS-CoV-2, SARS-CoV, bat coronavirus RaTG13, bat coronavirus CoVZC45, and bat coronavirus BM48-31. Detailed numbering is given according to SARS-CoV-2. One high-frequency mutation 25563G>T-(Q57H) locates on the ORF3a protein. Here, the red rectangle marks the Q57H position with its neighborhoods.

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