Fig. 6: The time evolution of 264 SARS-CoV-2 S protein mutations.

The red lines represent the RBD mutations that strengthen the infectivity of SARS-CoV-2 (i.e., ΔΔG is positive), the blue lines represent the RBD mutations that weaken the infectivity of SARS-CoV-2 (i.e., ΔΔG is negative), and the green lines are for S protein mutations that away from the RBD. The mutation with the highest frequency is D614G.