Table 1 Top 11 missense mutations that are prevalent in the United States.

Rank: US/World	Mutation	Protein	NC_U.S.	NC_World	Country	Date
Top 1/Top 1	23403A>G-(D614G)	Spike	10,496	37,294	CN	2020-01-24
					US	2020-02-28
Top 2/Top 2	14408C>T-(P323L)	NSP12(RdRp)	10,491	37,276	ES	2020-01-25
					US	2020-02-28
Top 3/Top 6	25563G>T-(Q57H)	ORF3a	7106	12,323	SG	2020-02-16
					US	2020-02-29
Top 4/Top 7	1059C>T-(T85I)	NSP2	6195	9322	SG	2020-02-16
					US	2020-02-29
Top 5/Top 3	28881G>A-(R203K)	Nucleocapsid	1825	15,837	AU	2020-01-27
					US	2020-02-28
Top 6/Top 4	28883G>C-(G204R)	Nucleocapsid	1824	15,798	AU	2020-01-27
					US	2020-02-28
Top 7/Top 5	28882G>A-(R203K)	Nucleocapsid	1823	15,797	AU	2020-01-27
					US	2020-02-28
Top 8/Top 11	28144T>C-(L84S)	ORF8	1727	3066	CN	2020-01-05
					US	2020-01-19
Top 9/Top 14	17858A>G-(Y541C)	NSP13(Helicase)	1478	1705	US	2020-02-20
					US	2020-02-20
Top 10/Top 15	17747C>T-(P504L)	NSP13(Helicase)	1439	1655	US	2020-02-20
					US	2020-02-20
Top 11/Top 16	27964C>T-(S24L)	ORF8	1176	1248	US	2020-03-09
					US	2020-03-09

The ranking of these 11 mutations in the US and the world are included in the table. NC_U.S. and NC_World represent for the total number of sequences with a specific mutation in the United States and in the world, respectively. The last column records the date that these eight missense mutations were detected for the first time in the world and in the United States. The second-last column records their corresponding countries, i.e., the country lists at the top shows where the mutations first detected, and the country lists at the bottom will always be the United States. Here, AU, US, CN, ES, and SG represent the Australia, the United States, China, Spain, and Singapore, respectively. We use ISO 8601 format YYYY-MM-DD as the date format.

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