Fig. 5: E-box annotation and location in the regulatory region of detoxification genes.

a Location of multiple E-boxes in the regulatory regions of clustered detoxification genes. Different types of E-boxes are annotated 3 kb upstream from transcriptional start sites (TSS) and shown with different colored rectangles. Daytime activated detoxification genes (red) and night activated detoxification genes (blue) are shown for a given cluster. b The number of detoxification genes relative to the distance between the E-box sequence and the TSS. c Annotated motifs of canonical E-boxes recognized by specific transcription factors.