Fig. 5: Global coordinated response of PKA-CWT and PKA-CDNAJB1 to ligand binding. | Communications Biology

Fig. 5: Global coordinated response of PKA-CWT and PKA-CDNAJB1 to ligand binding.

From: Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A

Fig. 5

Coordinated chemical shift changes analyzed with CONCISE for a PKA-CWT and b PKA-CDNAJB1. Changes in the free energy of binding of c PKA-CWT and d PKA-CDNAJB1 to ATPγN and PKI5–24. Black lines indicate the values obtained from ITC and pink lines correspond to values obtained from NMR measurements.

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