Fig. 5: Metabolic brain attributes vs. disease/behavior entropy.

Using a published dataset capturing the dynamics of metabolic supply mismatching energetic demand (higher relative cost vs. power) among n = 28 healthy subjects, we performed linear regression with n = 14 percent maximum disease and n = 13 behavior network entropy metrics as separate independent variables (matched VBM and functional components, colored orange and blue, respectively). Both regressions were found to be significant after correcting for multiple tests, p = 7e−7 and p = 0.03, for disease–structural and behavior–functional network data, respectively. Source data are provided in Supplementary Data 1.