Table 1 Summary of gene names of two stalled-ribosome rescue factors (srRFs) and one release factor (RF1), all of which have the GGQ motif, in mitochondria of four eukaryotes and E. coli.

From: A stalled-ribosome rescue factor Pth3 is required for mitochondrial translation against antibiotics in Saccharomyces cerevisiae

 

srRF1

srRF2

RF1a

S. cerevisiae

PTH4 YOL114C

PTH3 RSO55 YLR281C

MRF1 YGL143C

S. pombe

pth4 SPAC589.11

pth3 SPBC1105.18c

mrf1 SPAC2F7.17

H. sapiens

ICT1b MRPL58

C12orf65

MTRF1Lc MTRF1A

E. coli K-12

arfB yaeJ

–

prfA

  1. aMost bacteria have two RFs, RF1 (prfA) and RF2 (prfB), whereas mitochondria from many eukaryotes have an RF1 ortholog, but no RF2 ortholog.
  2. bNote that ICT1 in S. cerevisiae is assigned to a different gene (YLR099C).
  3. cIn contrast to eukaryotic unicellular organisms, human cells have another GGQ-containing protein gene, MTRF1, of unknown functions.
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