Fig. 5: Association between β-catenin abundance and LXR/RXR activation in NSFs. | Communications Biology

Fig. 5: Association between β-catenin abundance and LXR/RXR activation in NSFs.

From: β-catenin-promoted cholesterol metabolism protects against cellular senescence in naked mole-rat cells

Fig. 5

a Ingenuity Pathway Analysis (IPA) results showing pathways that were significantly affected (>4-fold-change) by β-catenin knockdown in NSFs. b Genes showing significant expression changes in β-catenin knockdown conditions. c Analysis of target genes regulated by β-catenin in NSFs by RT-PCR (left panels). Quantitative data are also shown (right-most graphs). d Schematic diagram illustrating potential links between β-catenin, ApoF, the LXR/RXR pathway, cholesterol biosynthesis and metabolism, lipid droplets, and senescence in NMR cells. e Schematic IPA diagrams showing LXR/RXR-dependent changes in gene expression potentiated by β-catenin knockdown.

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