Fig. 8: Induction of oxidative stress and decreased cell viability under β-catenin and ApoF knockdown conditions. | Communications Biology

Fig. 8: Induction of oxidative stress and decreased cell viability under β-catenin and ApoF knockdown conditions.

From: β-catenin-promoted cholesterol metabolism protects against cellular senescence in naked mole-rat cells

Fig. 8

a Immunofluorescence images showing elevated oxidative stress detected by CellRox upon β-catenin or ApoF knockdown. Scale bars, 20 μm. (left) Quantitative analysis of the CellRox in control, β-catenin, and ApoF knockdown NSFs (right). Data are expressed as the mean ± standard deviation (n = 3 biologically independent experiments) (lower graph); **P < 0.01, Student’s unpaired t test. b Alamar Blue assay showing decreased viability of NSFs upon β-catenin or ApoF knockdown, which was restored by treatment with NAC. Data are expressed as the mean ± standard deviation (n = 5 biologically independent experiments). **P < 0.01 and ***P < 0.001, Student’s unpaired t test.

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