Fig. 2: Establishment of a tumor immune-related prognostic signature (TIR signature) for melanoma. | Communications Biology

Fig. 2: Establishment of a tumor immune-related prognostic signature (TIR signature) for melanoma.

From: A four-gene signature predicts survival and anti-CTLA4 immunotherapeutic responses based on immune classification of melanoma

Fig. 2

a Cox proportional hazard regression model was used to construct a prognostic signature consisting of four genes (SEL1L3, HAPLN3, BST2, and IFITM1). The coefficient (β), P value, and hazard ratio of each gene were calculated by the model. b Kaplan–Meier curves of the overall survival of patients with high TIR risk scores and those with low TIR risk scores. Statistical significance was determined by the log-rank test. c All TCGA SKCM patients were ranked from the lowest to the highest TIR risk score. d The overall survival time and survival status of individual patients. The black dotted line represents the median TIR risk score that divides patients into low-risk and high-risk groups. e Heatmap of SEL1L3, HAPLN3, BST2, and IFITM1 expression levels. Rows represent genes and columns represent patients.

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