Fig. 5: Forskolin induced plasticity. | Communications Biology

Fig. 5: Forskolin induced plasticity.

From: Targeted volumetric single-molecule localization microscopy of defined presynaptic structures in brain sections

Fig. 5: Forskolin induced plasticity.The alternative text for this image may have been generated using AI.

Bassoon cluster measures in scanning dSTORM of 25 µm cryosections obtained from 300 µm acute brain sections of hippocampal mouse tissue; control group treated with DMSO (blue) experimental group treated with Forskolin solved in DMSO (magenta). One out of three animals showed highly significant changes (p < 0.001) in a Bassoon-cluster length (median ± 25th–75th percentile; DMSO: 0.490 ± 0.344–0.721 µm; Forskolin: 0.462 ± 0.333–0.681 µm) b localization counts (DMSO: 36 ± 16–91; Forskolin: 30 ± 14–77) and c volume (DMSO: 0.0132 ± 0.0056–0.0331 µm3; Forskolin: 0.0112 ± 0.0050–0.0283 µm3); Animal 2: d length (DMSO: 0.482 ± 0.343–0.709 µm; Forskolin: 0.482 ± 0.349–0.694 µm), e counts (DMSO: 33 ± 15–81; Forskolin: 33 ± 16–75.5), f volume (DMSO: 0.0125 ± 0.00544–0.0302 µm3; Forskolin: 0.0123 ± 0.00548–0.0285 µm3); Animal 3: g length (DMSO: 0.493 ± 0.345–0.729 µm; Forskolin: 0.507 ± 0.345–0.752 µm), h counts (DMSO: 35 ± 15–99; Forskolin: 36 ± 15–109), i volume (DMSO: 0.0127 ± 0.00526–0.0352 µm3; Forskolin: 0.0134 ± 0.00541–0.0381 µm3).

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