Fig. 2: BPA and BPS both affect central neurons.
From: Bisphenols exert detrimental effects on neuronal signaling in mature vertebrate brains
a BPA and BPS both affected the action potential in the Mauthner neuron. In high and low concentration, they significantly decreased the slope of the action potential. In high concentration, they additionally reduced the area I1. The sketch indicates the experimental setting for antidromic stimulation and intracellular recording from the Mauthner soma. The exemplary action potential from a control fish illustrates the interval in which slope and I1 were determined. b Changes in the occurrence of delayed potentials (DPs) due to backfiring (see Fig. 1b) after bisphenol exposition indicate an impact on synaptic transmission in the CNS. BPA (but not BPS) increased the occurrence of DPs in exposed fish. Low conc. = 10 µg L−1; high conc. = 1 mg L−1; N(Control) = 13 independent samples; N(10 µg L−1 BPA) = 12 independent samples; N(1 mg L−1 BPA) = 12 independent samples; N(10 µg L−1 BPS) = 11 independent samples; N(1 mg L−1 BPS) = 11 independent samples; differently treated groups are indicated by color; whiskers show the minimum and the maximum value, respectively; significant differences between groups and control are indicated by asterisk(s); * indicates P < 0.05; ** indicates P ≤ 0.01; **** indicates P ≤ 0.0001.
