Fig. 3: Both BPA and BPS affect auditory processing.
From: Bisphenols exert detrimental effects on neuronal signaling in mature vertebrate brains
a Sketch of experimental setting for acoustic stimulation and b an exemplary acoustically induced postsynaptic potential (PSP) from a control fish with illustration of how measurements were taken. c Both concentrations of BPA increased the PSP amplitude and decreased delay of the PSP relative to stimulus onset. Additionally, the high BPA concentration increased area I1 and decreased the slope of the PSP. BPS exposition also increased the amplitude of the acoustically induced PSP and I1. The high BPS concentration also increased the areas I2 and I3. Additionally, exposition to BPS shortened the delay. Low conc. = 10 µg L−1; high conc. = 1 mg L−1; N(Control) = 13 independent samples; N(10 µg L−1 BPA) = 12 independent samples; N(1 mg L−1 BPA) = 12 independent samples; N(10 µg L−1 BPS) = 11 independent samples; N(1 mg L−1 BPS) = 11 independent samples; differently treated groups are indicated by color; whiskers show the minimum and the maximum value, respectively; significant differences between groups and control are indicated by asterisk(s); * indicates P < 0.05; ** indicates P ≤ 0.01; *** indicates P ≤ 0.001; **** indicates P ≤ 0.0001.
