Fig. 4: Both BPA and BPS affect visual processing.
From: Bisphenols exert detrimental effects on neuronal signaling in mature vertebrate brains
a Sketch of experimental setting for visual stimulation to emphasize efficiency of the system: only stimulation needs to be changed, but recording is kept (cf. Figs. 2a and 3a). b shows an exemplary visually induced PSP from a control fish and how measurements were taken. c Both BPA and BPS affected the visually induced PSP. BPA and BPS significantly reduced its amplitude. BPA in high concentration (but not BPS) additionally reduced PSP slope. In contrast, after exposition to BPS and to low BPA concentration the beginning of the PSP (first 150 ms; I1 and I2) was reduced in area. Low conc. = 10 µg L−1; high conc. = 1 mg L−1; N(Control) = 8 independent samples; N(10 µg L−1 BPA) = 12 independent samples; N(1 mg L−1 BPA) = 12 independent samples; N(10 µg L−1 BPS) = 11 independent samples; N(1 mg L−1 BPS) = 11 independent samples; differently treated groups are indicated by color; whiskers show the minimum and the maximum value, respectively; significant differences between groups and control are indicated by asterisk(s); * indicates P < 0.05; ** indicates P ≤ 0.01; *** indicates P ≤ 0.001; **** indicates P ≤ 0.0001.
