Fig. 4: Phylogenetic relationship and genotypic variation in selected genes of S. Typhimurium U288 and monophasic S. Typhimurium ST34 strain S04698-09.

Mid-point rooted maximum likelihood tree based on 1859 SNPs in the recombination-purged variation in the core genome with reference to S. Typhimurium strain SL1344. Lineages associated with the U288 (green), closely related strains (black) and ST34 S04698-09 (purple) are indicated. Scale bar indicates the estimated number of SNPs based on the genetic distance as a fraction of total SNPs. This collection comprised 134 S. Typhimurium U288 isolates from animals and human infections in the UK placed in the context of 16 S. Typhimurium isolates from animals and human that were closely related but outside of the main U288 clade. Monophasic S. Typhimurium strain S04698-09 is included as an outgroup. The presence of allelic variants associated with HDCS, plasmid replicons and resistance genes are indicated by bars colour coded as indicated in the key (inset).