Fig. 3: LCMV-Docile failed to activate IFN-I production pathway.
From: Slow viral propagation during initial phase of infection leads to viral persistence in mice
GM-CSF induced BMDCs were infected with LCMV-WE, LCMV-Docile, or co-infected at the indicated MOI 10, 1, 0.01 or 0.001. a co-stimulatory molecules expression was monitored by flow cytometry 24 h post-infection on CD11c+ MHC-II+ BMDCs (MOI = 1) (n = 6, gating strategy is shown in Supplementary Fig. 5a). b IFN-α concentration was determined in the supernatant of LCMV infected BMDCs 24 h post-infection (n = 9). c IL-6, d TNF-α, e IL-1β levels were measured in the supernatant of LCMV infected BMDCs 24 h post-infection (n = 7, dotted line indicated minimum detection limit). (Error bars show SEM, *p < 0.05, **p < 0.01, ***p < 0.001, and ns indicates statistically not significant between the indicated groups).
