Fig. 1: Structure of Pol II–RPAP2 complex.
From: Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2
a Primary architecture of RPAP2. The color code is used throughout. The black line below indicates confidently modeled regions. Dashed black line indicates region with backbone trace. α-helices and the insertion β-strands are indicated. b Ribbon model viewed from the front (Pol II, gray except RPB5, magenta; RPAP2, green except RPAP2 insertion, cyan). The RPAP2 zinc metal is displayed as a light blue sphere. The canonical location of the Pol II mobile clamp and the RPB4/RPB7 stalk are outlined by dashed lines. This and other structural figure panels were prepared with PyMol (version 2.3.4). c–e Detailed views of interactions between RPAP2 insertion and RPB1 jaw domain and between RPAP2 and RPB5. Side chains of residues in the interaction interfaces are shown as sticks and are labeled.
