Table 1 Antibody responses to single immunization in Syrian hamsters.

From: Multivalent nanoparticle-based vaccines protect hamsters against SARS-CoV-2 after a single immunization

  

RBD IgG endpoint titera

Neutralizing antibody titerb

Vaccine group

Animal #

Replicate

Replicate

Replicate

Geometric mean

Geometric SD factor

Replicate

Replicate

Replicate

Geometric mean

Geometric SD factor

1

2

3

  

1

2

3

  

PBS

1

<10

<10

<10

  

<10

<10

<10

  
 

2

<10

<10

<10

<10

–

<10

<10

<10

<10

–

 

3

<10

<10

<10

  

<10

<10

<10

  

MS2-SA VLP

1

<10

<10

<10

  

<10

<10

<10

  
 

2

<10

<10

<10

<10

–

<10

<10

<10

<10

–

 

3

<10

<10

<10

  

<10

<10

<10

  

VLP-S2Pro

1

20,480

40,960

20,480

  

320

640

320

  
 

2

81,920

40,960

81,920

35,113

1.78

640

320

320

373

1.36

 

3

20,480

20,480

40,960

  

320

320

320

  

VLP-S6Pro

1

81,920

81,920

81,920

  

640

640

640

  
 

2

81,920

81,920

81,920

70,225

1.36

640

640

640

549

1.36

 

3

40,960

81,920

40,960

  

320

640

320

  
  1. aViral antibody endpoint titers against the RBD (receptor-binding domain) from three independent assays (three animals in each group). Endpoint titers using 2-fold diluted sera were expressed as the reciprocal of the highest dilution with an optical density at 490 nm cutoff value >0.15; sera were collected on day 28 after immunization.
  2. bViral neutralization titers from three independent assays (three animals in each group). Endpoint titers using twofold diluted sera were expressed as the reciprocal of the highest dilution that completely prevented cytopathic effects; sera were collected on day 28 after immunization.
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