Fig. 4: IP3R1 domains at the cytosolic-lipid bilayer interface.
From: Cryo-EM structure of type 1 IP3R channel in a lipid bilayer
a The ILD (light-green) and LNK domain (orange) form a metastable nexus connecting the CY (gray) and TM (purple) regions in the tetrameric IP3R1 channel; viewed along the membrane plane. The right panel shows a zoomed-in view of the domains (indicated by the gray dashed line in the left panel) at the cytosolic-membrane interface viewed from cytosol along the four-fold axis. b The interface between ILD and the LNK/TM6 of neighboring subunits overlapped with corresponding EM densities (displayed at 4σ). c Close-up view of Zn2+ binding site in LNK domain; residues in the C2H2-like Zn2+ finger are labeled; the density corresponding to Zn2+ is depicted as magenta mesh, contoured at 15σ.
