Fig. 2: Transcriptomic analysis of macrophage infection by LF82. | Communications Biology

Fig. 2: Transcriptomic analysis of macrophage infection by LF82.

From: The Crohn’s disease-related bacterial strain LF82 assembles biofilm-like communities to protect itself from phagolysosomal attack

Fig. 2

a Expression data for the LF82 genes during infection of THP1 macrophages. Selected genes with highly significant expression changes at 6 h of P.I. are noted. b Expression data for the human genes from RNA-seq experiments at 1 and 6 h of P.I. Gene markers of the M1 pro inflammatory macrophage phenotype are noted. c Representation of the main E. coli pathways presenting large transcriptomic responses at 6 h of P.I. of THP1 macrophages (top 500 genes ranked on DE-seq). These networks were constructed with cytoscape and were based on the data presented on Supplementary Fig. 1. Upregulated genes (green) and downregulated genes (orange). d Annotation of the biofilm formation pathways adapted from KEGG ko2026 according to RNA-seq data at 6 h of P.I. vs. planktonic exponential growth.

Back to article page