Fig. 8: Gap junction regulators and the effect on axial growth.
From: Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish
Simplified illustration summarizing the relation between (un)coupling of retinal gap junctions and axial eye growth. We hypothesize, based on reported literature and the outcome of this study (asterisk), that the (un)coupling of retinal gap junctions may play an intermediate role in controlling emmetropization. The exact mechanism of how Cx35/Cx36 uncoupling leads to reduce axial eye growth is unclear (dotted line arrow).
