Fig. 2: Plasma methionine-related metabolites and its correlation with animal longevity.
From: Plasma methionine metabolic profile is associated with longevity in mammals
Individual plasma correlation of the metabolites with animal longevity involved in the transmethylation and transsulfuration pathways (a) and vitamin B6 metabolites (b). Dashed lines refer to reactions in which more than one enzyme is involved. Grey-shaded boxes refer to non-detected metabolites. Pearson correlation was performed. Minimum signification level was set at p < 0.05. All metabolites were log-transformed in order to accomplish the assumptions of normality. Data values are obtained from four (mice and cows), five (rats, rabbits, guinea pigs, sheep, dogs, pigs, cats and horses) or six (humans) specimens. Enzyme codes refer to: MS methionine synthase, BHMT betaine-homocysteine S-methyltransferase, MAT methionine adenosyltransferase, MTs methyltransferases, AHCYL adenosylhomocysteinase-like 1, CBS cystathionine-β-synthase, CTH cystathionine-γ-lyase, PDXK pyridoxal kinase, PDXP pyridoxal phosphatase.
