Fig. 3: Choice environment reduces network connectivity and increases average shortest distance in a 5-HT2A-dependent manner. | Communications Biology

Fig. 3: Choice environment reduces network connectivity and increases average shortest distance in a 5-HT2A-dependent manner.

From: Serotonin signaling modulates aging-associated metabolic network integrity in response to nutrient choice in Drosophila melanogaster

Fig. 3: Choice environment reduces network connectivity and increases average shortest distance in a 5-HT2A-dependent manner.

a Dot plots showing the frequencies of node connectivity (degree) exhibit a decrease in the number of high-degree nodes in the heads of control flies that fed on a choice diet (compared to that of flies fed a fixed diet). Switching to a fixed diet for 48 h is sufficient to restore the high-degree nodes. Importantly, node connectivity of 5-HT2A mutants is not influenced much by diet, suggesting that the dietary effects are mediated by serotonin signaling. b, c Exposure to a choice diet also increases the average of shortest distance in networks and such effects are dependent on 5-HT2A in both heads (c) and bodies (d). P values on the top of the violin plots are obtained from two-way ANOVA.

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